Naloxone research

paperandpenWe've put this collection in the order that the research was released with the most recent first. Wherever possible we've linked to the full research article, however in some cases we have only linked to the abstract as the article itself is behind a paywall.

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National Forum on Drug-Related Deaths in Scotland - Annual Report 2011/12

on . Posted in Research

The National Forum on Drug-Related Deaths 2011/12 Annual Report provides an update on the Forum's work between August 2011 and November 2012. The report provides a number of observations on key areas of work to help reduce drug-related deaths in Scotland including two recommendations.

The report provides the Forum's response to the National Records of Scotland's 2011 drug-related deaths report published on 17 August 2012. Also the Forum's insights from Scotland's second Drug-Related Deaths Database report (2010 deaths) which provides more detailed socio-demographic information and treatment history on each drug-related death in 2010. An update on Scotland's National Naloxone Programme is also provided.

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Opioid overdose rates and implementation of overdose education and nasal naloxone distribution in Massachusetts: interrupted time series analysis

on . Posted in Research

OEND programs equipped people at risk for overdose and bystanders with nasal naloxone rescue kits and trained them how to prevent, recognize, and respond to an overdose by engaging emergency medical services, providing rescue breathing, and delivering naloxone.

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General Practitioner Engagement with the Scottish National Naloxone Programme: A Needs Assessment Project

on . Posted in Research

The Scottish National Naloxone Programme was launched in November 2010 following successful pilots in Scottish sites. The aim of the programme is to reduce Scotland's high number of drug-related deaths (DRDs) caused by opiate overdose.

This needs assessment was commissioned to ensure GPs' views and knowledge are considered to maximise engagement of GPs in the Scottish National Naloxone Programme.

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Training bystanders to spot drug overdoses can reduce deaths

on . Posted in Research

Training bystanders to recognize and respond to drug overdoses can significantly reduce the number of fatalities, finds a study published on bmj.com today.Overdoses of opioid drugs are a major cause of emergency hospital admissions and preventable death in many countries. In Massachusetts, annual opioid-related overdose deaths have exceeded motor vehicle deaths since 2005, so several strategies have been introduced to tackle this growing problem.

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Cost-Effectiveness of Distributing Naloxone to Heroin Users for Lay Overdose Reversal

on . Posted in Research

This study's objective was to estimate the cost-effectiveness of distributing naloxone, an opioid antagonist, to heroin users for use at witnessed overdoses. It concluded that "Naloxone distribution to heroin users is likely to reduce overdose deaths and is cost-effective, even under markedly conservative assumptions."

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National Naloxone Programme Scotland Monitoring Report – naloxone kits issued in 2011/12

on . Posted in Research

This report presents data on the number of 'take-home' naloxone kits issued as part of the national programme during 2011/12. Data are presented separately for kits issued in the community and kits issued by prisons, prior to prisoner release.

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Increasing access to naloxone in BC to reduce opioid overdose deaths

on . Posted in Research

Opioid overdose is a public health issue in British Columbia. In 2009, more than 200 deaths were identified as illicit drug deaths (IDD), opiates were found in 60%, and an additional 74 deaths were in persons prescribed opioid medication.

In May 2011, the BC Coroners Service released a warning about a spike of heroin-related deaths due to increased heroin potency. Unintentional death from opioid overdose is preventable with education and timely administration of naloxone, an opioid antagonist. In BC, the current lack of naloxone availability outside primary care, hospital, and ambulance settings limits its lifesaving potential.

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N-ALIVE

on . Posted in Research

The N-ALIVE project (NALoxone InVEstigation) has two stages: the Pilot randomized trial (n=5,600) and the subsequent main randomised trial. Ultimately a total of 56,000 participants are planned to be recruited in total. The N-ALIVE trial is a large prison-based randomized controlled trial, designed to test the effectiveness of giving naloxone-on-release to prisoners with history of heroin use to prevent fatal opiate overdoses. (NOTE this is not the research outcomes but an overview of ongoing research)

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The NTA overdose and naloxone training programme for families and carers.

on . Posted in Research

In 2010 the NTA helped 16 pilot sites across England to train the carers and relations of opiate misusers to respond to drug overdoses and use the antidote naloxone. The project appears to have helped save lives. This was despite difficulties with recruitment, and limited evidence that carers are the most appropriate people to receive the training. While those carers who were trained said they found it valuable, a wider impact may be possible if the training focuses on all service users at risk of opioid overdose.

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