Take Home Naloxone in the UK

Naloxone (provided under the brand names Prenoxad and Nyxoid in the UK) is a medication used to reverse opioid overdose. Since 2015, this medication has been more widely available in the UK as a ‘take home’ emergency medication.


This website aims to be a hub for information, guidance, news and research on Take Home Naloxone (THN). The main focus is on THN in the UK, although we have included select pieces of information on the supply of naloxone internationally.

PHE Guidance

Updated 18 February 2019
Public Health England have released updated guidance on take home naloxone in the UK, entiled ‘Widening the Availability of Naloxone’. This can be found on the PHE website.
  • Drug services can supply naloxone without a prescription
  • Products that drug services can supply
  • Responsibility for deciding who can supply naloxone
  • People who can be supplied naloxone by a drug service
  • Using naloxone to save a person’s life without their permission
  • Clinical governance in drug treatment services
  • Guidance for hostels, homeless shelters and housing associations
  • Side effects associated with naloxone

Middle-aged generation most likely to die by suicide and drug poisoning

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A generation of people born in the 1960s and 1970s, known as Generation X, are dying from suicide or drug poisoning in greater numbers than ever. ONS data for England and Wales has shown that in the late 1980s to early 1990s, the age at which most people died by taking their own lives or drug poisoning was concentrated around this generation, when they were in their 20s.

Stop the deaths

This year the Scottish Drugs Forum  #StopTheDeaths campaign highlights the role we all have in recognising and intervening when a person overdoses.

Overdose is not a rare occurrence and the difference between an overdose and a fatal overdose depends upon the immediate actions of people present at the time. You could save a life by recognising an overdose.  

#StopTheDeaths images © SDF 2021


NYC Vending Machines to Distribute Free Naloxone and Other Supplies

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Before the end of 2022, New York City residents should be able to access naloxone, sterile syringes and other harm reduction supplies from a handful of public vending machines—for free. It’s a new approach from the city, where drug overdoses are continuing to rise, especially for Black residents.

Broadening The Reach

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We need to prioritise naloxone supply in high-risk settings if we’re going to properly tackle drug-related deaths, says Mohammed Fessal. Proactive responses are vital, and naloxone supply must be a crucial priority in efforts to reduce the death rate. At Change Grow Live, a key focus in our harm reduction work over the last five years has been increasing the availability of naloxone to those within structured treatment, as well as their family, friends, and wider network.
(See page 13 of linked PDF for article)

To save lives, overdose antidote should be sold over-the-counter, advocates argue

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Louise Vincent figures her group, the North Carolina Survivors Union, saves at least 1,690 lives a year. The harm-reduction and syringe service program in Greensboro, N.C., distributes the opioid overdose reversal medication naloxone to people who use drugs. Research suggests this approach is effective, since people who use drugs are most likely to witness an overdose and administer naloxone.

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