The American Medical Association commends the Biden Administration for responding to the spike in drug overdoses with an evidence-based, humane approach to increasing access to care for patients with a substance use disorder and harm reduction services. This plan recognizes that individuals, families and communities have been decimated by this public health epidemic. The AMA has urged a public health response that focuses on how to best treat substance use disorders as well as prevent overdoses and encourage recovery. This comprehensive approach recognizes that we need an inclusive federal approach—free of stigma—based on best available data. An inclusive approach means embracing the variety of harm reduction strategies. We have advocated for naloxone to be sold over the counter, for fentanyl test strips, for widespread access to sterile needle and syringe exchange services.