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Device for Opioid Overdoses Releases Naloxone Automatically

Naloxone is an antidote that prevents opioids from binding to brain receptors, but when a person does overdose it’s often too late for them to administer the life-saving drug themselves, as they may be incapacitated. Now, researchers at Purdue University have developed a smart system, which includes an implantable naloxone-releasing device, that can automatically halt an overdose without anyone’s intervention.

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Zoe Carre: Take home naloxone is not reaching those who most need it

Naloxone is key is to addressing the current opioid crisis, but poor systemic distribution means it isn’t saving the lives it should, says Zoe Carre. Drug-related deaths are at record high levels across Britain. While estimates suggest that illicit opiate use is less prevalent than the use of other drugs, data show that nearly 9 in 10 drug-related deaths across the UK involved an opioid. Many of these deaths could be prevented by supplying naloxone to people likely to experience or witness an opioid overdose.

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A single-dose antidote may help prevent fentanyl overdoses

…researchers developed a new naloxone-based antidote to outlast synthetic opioids by creating nanoparticles in which naloxone molecules are tangled up with a biodegradable polymer called polylactic acid. Water and enzymes in the body slowly break down these nanosized tangles, gradually releasing naloxone.

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