A single-dose antidote may help prevent fentanyl overdoses

…researchers developed a new naloxone-based antidote to outlast synthetic opioids by creating nanoparticles in which naloxone molecules are tangled up with a biodegradable polymer called polylactic acid. Water and enzymes in the body slowly break down these nanosized tangles, gradually releasing naloxone.

Overdoses linked to fentanyl may need multiple doses of antidote naloxone

New and more potent fentanyl may need multiple doses of the overdose antidote naloxone as deaths due to illicit versions of the opioid continue to rise, according to the Centers for Disease Control and Prevention. The agency issued a new public health alert to local health departments and related law enforcement on rising numbers of deaths related to fentanyl and similar products.

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Concentrated naloxone nasal spray as good as injection

A new study published by the scientific journal Addiction has found that a concentrated 2mg intranasal naloxone spray delivers naloxone as effectively, over the critical first 15 minutes, as the standard 0.4mg intramuscular (IM) naloxone injection. The research was co-authored by Professor Sir John Strang and Dr Rebecca McDonald, National Addiction Centre, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London.

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