Take-Home Naloxone for the Emergency Interim Management of Opioid Overdose: The Public Health Application of an Emergency Medicine

Naloxone is a well-established essential medicine for the treatment of life-threatening heroin/opioid overdose in emergency medicine. Over two decades, the concept of ‘take-home naloxone’ has evolved, comprising pre-provision of an emergency supply to laypersons likely to witness an opioid overdose (e.g. peers and family members of people who use opioids as well as non-medical personnel), with the recommendation to administer the naloxone to the overdose victim as interim care while awaiting an ambulance.

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Community responders more likely to seek help during overdose

Community members responding to an overdose with naloxone are more likely to seek emergency help when naloxone does not work or takes more time to work. Published in Drug and Alcohol Dependence, the results show several factors associated with calling emergency services when helping someone with naloxone.

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Hospital Observation Upon Reversal (HOUR) With Naloxone: A Prospective Clinical Prediction Rule Validation Study

St. Paul’s Early Discharge Rule was derived to determine which patients could be safely discharged from the emergency department after a 1‐hour observation period following naloxone administration for opiate overdose. The rule suggested that patients could be safely discharged if they could mobilize as usual and had a normal oxygen saturation, respiratory rate, temperature, heart rate, and Glasgow Coma Scale score.

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Finding a Needle in a Haystack: Take-Home Naloxone in England 2017/18

Release surveyed each of the 152 local authority areas in England, as local authorities are responsible for commissioning drug services, which give out take-home naloxone. The report includes findings on the availability of take-home naloxone across local authority areas, the scale of take-home naloxone supply in community settings, and coverage among people who use opiates and opiate clients in drug treatment.

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Harm Reduction Database Wales: Take Home Naloxone 2015-16

The supply of ‘Take Home Naloxone’ (THN) was initiated (pilot project) in 2009 as a harm reduction tool used to prevent fatal opioid poisonings, and has since been fully implemented across all health boards in Wales. This report provides data on the training and provision of THN kits from 49 registries across Wales recorded on the Harm Reduction Database Wales (HRD) during the period 1st April 2015 to 31st March 2016.

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