In the US fentanyl is in a large portion of the drug supply. We have now also started seeing it appearing in some parts of the UK. Naloxone will work on fentanyl overdose, although it has to be understood that because of the speed of fentanyl overdose responding needs to be far faster. Also the American Centers for Disease Control and Prevention (CDC) have said “Multiple doses of naloxone may need to be administered per overdose event because of fentanyl and fentanyl analog’s increased potency relative to other opioids,”.
If fentanyl is suspected to be in the drug supply in an area it would be sensible to supply people with multiple naloxone kits.